Immunopathogenesis of conjunctival scarring in trachoma
نویسندگان
چکیده
منابع مشابه
Conjunctival transcriptome in scarring trachoma.
Trachoma is a poorly understood immunofibrogenic disease process, initiated by Chlamydia trachomatis. Differences in conjunctival gene expression profiles between Ethiopians with trachomatous trichiasis (with [TTI] or without [TT] inflammation) and controls (C) were investigated to identify relevant host responses. Tarsal conjunctival swab samples were collected for RNA isolation and C. trachom...
متن کاملBacterial infection in scarring trachoma.
PURPOSE To assess whether non-chlamydial bacterial infection is associated with trachomatous scarring in adults. METHODS This was a case-control study of 360 cases with trachomatous scarring but without trichiasis, and 360 controls without scarring. All participants underwent clinical examination, and a swab was taken from the inferior conjunctival fornix. Samples were inoculated onto blood a...
متن کاملIn Vivo Confocal Microscopy in Scarring Trachoma
OBJECTIVE To characterize the tissue and cellular changes found in trachomatous scarring (TS) and inflammation using in vivo confocal microscopy (IVCM). DESIGN Two complimentary case-control studies. PARTICIPANTS The first study included 363 cases with TS (without trichiasis), of whom 328 had IVCM assessment, and 363 control subjects, of whom 319 had IVCM assessment. The second study includ...
متن کاملConjunctival MicroRNA Expression in Inflammatory Trachomatous Scarring
PURPOSE Trachoma is a fibrotic disease of the conjunctiva initiated by Chlamydia trachomatis infection. This blinding disease affects over 40 million people worldwide yet the mechanisms underlying its pathogenesis remain poorly understood. We have investigated host microRNA (miR) expression in health (N) and disease (conjunctival scarring with (TSI) and without (TS) inflammation) to determine i...
متن کاملNew model of conjunctival scarring in the mouse eye.
AIMS To establish a simple model of conjunctival wound healing in the mouse eye. METHODS 4 week old BABL/c mouse eyes were studied over a 14 day period. Surgical procedure under general anaesthesia involved a blunt dissection of the conjunctiva performed by injection of 25 microliters of PBS via a 27 gauge needle into one eye, while the contralateral eye was used as control. Mice were assesse...
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ژورنال
عنوان ژورنال: Eye
سال: 1998
ISSN: 0950-222X,1476-5454
DOI: 10.1038/eye.1998.104